In this issue:

• Gold Standard JAX^® Mice for type 2 diabetes and obesity research
• BALB/cJ - A valuable strain for immunological studies
• Diet-induced obese (DIO) B6 mice available for purchase
• Quick, accurate, and affordable gene expression services
• JAX^® Mice strains under development
• Recent articles by Jackson Laboratory professors

Gold Standard JAX^® Mice for Type 2 diabetes and obesity research

• BKS.Cg-m +/+ Lepr^db/J (000642) is one of the most widely used diabetes mouse models. This mouse develops hyperinsulinemia, insulin resistance, hyperglycemia, glucose intolerance, and abnormal islet morphology.
  
  
• NONcNZO10/LtJ (004456) exhibits a human-like polygenic diet-induced diabetes. This mouse is characterized by early weight gain, moderately-altered behavioral and endocrine phenotypes, and a late-onset transition from impaired glucose tolerance to stable non-fasting hyperglycemia.
  
  
• NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (005557) can be used as a recipient of diabetic T cells in transfer experiments and do not need to be irradiated.
  
  
• B6.129-Pparg^tm2Rev/J (004584) is suitable for researching the molecular links between peroxisome proliferator activated receptor gamma (PPARg), fat cell function, and susceptibility to diabetes and metabolic disease.
  
  
• TALLYHO/JngJ (005314) is characterized by moderate obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia, glucose intolerance, and enlarged pancreatic islets.

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BALB/cJ - A valuable strain for immunological studies
BALB/cJ (000651) mice are frequently used for a variety of immunological studies, in part because they demonstrate TH2-biased immune responses. BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies. Mammary tumor incidence is normally low, but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor incidence and age of onset. BALB/c mice develop other cancers later in life, including reticular neoplasm, primary lung tumors, and renal tumors.

• Physiological data (PDF)
• Phenotypic data (Mouse Phenome Database)
• Strain data sheet

To order this mouse strain, call 1-800-422-6423 or 1-207-288-5845. You can also email orderquest@jax.org.

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Diet-induced obese (DIO) B6 mice available for purchase
Are you researching C57BL/6J mice on a high-fat diet? Do you have extra vivarium space to feed and maintain these mice? The Jackson Laboratory provides diet-induced obese (DIO) C57BL/6J. You can receive the study-ready mice on a regular basis, and you don't need to spend resources getting the mice ready for research. Learn more about our DIO Service or sign up for our weekly inventory DIO mice report email.

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A quick, accurate, affordable way to analyze gene expression
Need a way to analyze gene expression in one or several mouse tissues? Our new Gene Expression Service may be just what you're looking for. We have successfully performed this service thousands of times for our own scientists and are now offering it to the broader scientific community.

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New JAX^® Mice strains under development
You can find more information about these and other JAX^® Mice strains by searching the JAX^® Mice Database. If you are interested in submitting your unique research strain(s) to our international repository for mouse models, see our Strain Donation Form.

• B6.129-Adipoq^tm1Chan/J (008195) Adiponectin-deficient mice (Adipoq^-/- or Adipo^-/-) may be used to study obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
  
  
  
• B6;129-Smn1^tm2Mrph/J (007246) This strain functions as a reporter strain for survival motor neuron 1 (Smn1) in the heterozygous state. Exons 1 through 8 of the mouse Smn1 gene (12.8 kb) were replaced with lacZ.
  
  
  
• B6.Cg-Cav1^tm1Mls/J (007083) Homozygous caveolin, caveolae protein 1 (Cav1) knockout mice are exercise-intolerant when challenged, resistant to diet-induced obesity, and slightly hyperphagic. They may be used to study vesicular and cholesterol trafficking, signal transduction, and tumor suppression.
  
  
  
• B6.Cg-Tg(Ela1-TAg*)289Mjt/J (008247) These T1-147 transgenic mice (harboring the E1-T147 transgene) develop metastatic pancreatic acinar cell cancer as a result of expression of the 1-147 amino acid fragment of Simian Virus 40 large T antigen (TAg) directed to pancreatic acinar cells by the rat elastase 1 (Ela1 or E1) upstream control region.
  
  
  
• B6.Cg-Tg(SOD1*G37R)42Dpr/J (008342) These high-expressing G37R(42) (or G37R-SOD1 line 42) transgenic mice may be used to study neuromuscular disorders, including amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).
  
  
  
• B6.Cg-Tg(SOD1*G85R)148Dwc/J (008248) G85R-SOD1 transgenic mice may be used to study neuromuscular disorders, including amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).
  
  
  
• FVB.129S2(B6)-Hmox1^tm1Poss/J (008311) Mice that are homozygous for this heme oxygenase (decycling) 1 (Hmox1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency (or are not produced) from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be used to study hemochromatosis, inflammation and iron metabolism.
  
  
  
• FVB/N-Tg(Ins2-IAPP)RHFSoel/J (008232) These RIPHAT transgenic mice express human islet amyloid polypeptide (h-IAPP) under the regulatory control of the rat insulin II promoter and may be used to study the beta-cell destruction and islet amyloid deposition associated with non-insulin-dependent diabetes mellitus (NIDDM) or type 2 diabetes, as well as beta-cell apoptosis.
  
  

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Recent articles by Jackson Laboratory professors

Ackerman SL, Cox GA. From ER to Eph receptors: new roles for VAP fragments. Cell 2008; 133:949-51.PubMed:[18555770]

King LE Jr, McElwee KJ, Sundberg JP. Alopecia areata. Curr Dir Autoimmun 2008; 10:280-312. PubMed:[18460892]

Kong Y, Yoshida S, Saito Y, Doi T, Nagatoshi Y, Fukata M, Saito N, Yang SM, Iwamoto C, Okamura J, Liu KY, Huang XJ, Lu DP, Shultz LD, Harada M, Ishikawa F. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 2008; 22:1207-13. PubMed:[18418410]

Lee JM, Tiong J, Maddox DM, Condie BG, Wray S. Temporal migration of gonadotrophin-releasing hormone-1 neurones is modified in GAD67 knockout mice. J Neuroendocrinol 2008 Jan; 20(1):93-103. PubMed:[18081557]

Li S. Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia. Leuk Lymphoma 2008 Jan; 49(1):19-26. PubMed:[18203007]

Rehg JE, Sundberg JP. Utility of antiPax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice. Comp Med 2008; 58(3):246-252. PubMed:[18589866]

Su Z, Tsaih S-w, Szatkiewicz J, Shen Y, Paigen B. Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ. J Lipid Res 2008 Jul; 49(7):1500-10. PubMed:[18362393]

Xia C-H, Liu H, Cheung D, Wang M, Cheng C, Du X, Chang B, Beutler B, Gong X. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet 2008 Jun; 17(11):1605-12. PubMed:[18263894]

Thank you for your interest in JAX^® Mice and Services.

Jennifer Guilmet
Regional Representative
The Jackson Laboratory

Email: jennifer.guilmet@jax.org
Tel: 617-780-2566